ANALYSIS OF SUBTLE CHANGES IN BIOMEDICAL SIGNALS BASED ON ENTROPY PHASE PORTRAIT

Abstract

A new method for evaluating subtle changes in biomedical signals, caused by external influences on the human organism, is proposed. The method is based on the analysis of chaoticness of the studied parameter, which is calculated in a sliding window along an array of observed values using different entropy estimations. A distinctive feature of the method is the transition from the calculated entropies to their mapping on the phase plane and estimation of the integral parameters of the obtained graphic image (the entropy phase portrait), in particular, the area of the convex hull.
The diagnostic value of the proposed approach in the processing of real clinical data was demonstrated, obtained under conditions of increasing physical activity, coronary artery bypass surgery and intravenous drip infusion.